Abstract

Background: For esophageal cancer, no viable non-invasive detection technologies are available today. In this investigation, a newly developed IVD cancer diagnostic technology named Cancer Differentiation Analysis Technology (CDA) was investigated for esophageal cancer detection. In a CDA technology, multi-level and multi-parameter information is collected using a medical device fabricated by Anpac Bio-Medical Science Co., Ltd. which measures information relating to both protein fragments and cellular signals in blood samples in a single test.

Methods: Blood samples were collected in EDTA vacutainer tubes, with 49 esophageal cancer patients and 303 healthy individuals (control group). CDA data was then collected, and analysis was carried out.

Results: The results showed significant statistical difference between esophageal cancer and control groups with P value < 0.05 (Table 1). Also, CDA values at different stages of esophageal cancer samples showed possible effectiveness using CDA technology for early stage esophageal cancer detection (P value < 0.05 between stage I esophageal cancer and control groups). In addition, using a reasonable cut-off value, its sensitivity and specificity are about 70% and 90%, respectively.

Conclusions: CDA technology is a promising approach for esophageal cancer diagnostics including early stage diagnostics.

Keywords: Esophageal Cancer; CDA

• ASCO Annual Meeting 2015. Investigations of an improved esophageal cancer. Category : Gastrointestinal (Noncolorectal) Cancer. 2015. e15059.
  Author(s):Geng Xi Jiang, Junjie Wu, Hua Xiao, Xiao Gang Zhang, Bao Xia Wang, Li Xin Yang, Qiang Li, Xing Tang, Da Lou, Xuedong Du, Chris Chang Yu; Department of Cardiothoracic Surgery, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China; “1 State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University 2Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University “, Shanghai, China; Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China; Department of Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China, China; AnPac Bio-Medical Science and Technology Co.,LTD, Shanghai, China; Anpac Bio-Medical Science Co Ltd, Shanghai, China.