Abstract

Background: For esophageal cancer, no viable non-invasive detection technologies are available today. In earlier investigations, Cancer Differentiation Analysis (CDA) Technology which measures information relating to both protein fragments and cellular signals in blood samples in a single test has showed a significant advantage in esophageal cancer diagnosis. 

Methods: Blood samples from 105 individuals in EDTA tubes were collected from Shanghai Changhai Hospital, China, between July and December 2014, CDA and endoscopy tests were carried out on all samples before clinically diagnosed. A performance predication model of CDA and endoscopy test results was built using pROC package in R Language for the data of Area Under the Curve (AUC) and CDA threshold values. Further analysis was carried out based on the CDA threshold values. 

Results: Out of the 105 individuals, samples from 6 individuals diagnosed as esophageal benign diseases were selected as control group. 99 samples from individuals diagnosed as esophageal cancer, of which 3 and 82 cases were adenocarcinoma and squamous carcinoma, 2, 26, 33, 31 and 7 cases were classified as stage 0,I,II, III, IV, respectively. Details of AUC results of endoscopy, and CDA plus endoscopy for each group were given in Table 1 below. 

Conclusions: Even though the sensitivity of the endoscopy is usually high due to its pathological examination, this investigation showed that CDA technology could further enhance the diagnosis sensitivity of endoscope, especially for early stage of esophageal cancer, and it (CDA) can be an effective complementary tool to clinical diagnosis and operation determination while obtaining the pathological information via endoscopy. In conclusion, CDA technology is of great value in esophageal diagnosis and therapeutic decision-making

• Gastrointestinal Cancers Symposium (San Francisco). 2017. Prevention, Diagnosis, and Screening. Category: Cancers of the Esophagus and Stomach. Session Type and Session Title: Poster Session A: Cancers of the Esophagus and Stomach. Abstract Number: 42. Poster Board Number: Poster Session A Board #E20
  Author(s):Gengxi Jiang, Hongmei Tao, Xing Tang, Da Lou, Yue Lin, Yutao Li, Junjie Wu, Baoxia Wang, Ning Ding, Pengkun Xu, Xing He, Hao Hu, Chris Chang Yu, Hezhong Chen, Xuedong Du; Department of Thoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China, China; AnPac Bio-Medical Science and Technology Co., LTD, Shanghai, China; Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China, China; Changhai Hospital, Shanghai, China; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu, China; Department of Basic Medicine, Hainan Medical College, Haikou, Hainan, China; Unit 92058 of Chinese people’s Liberation Army, Zhoushan, Zhejiang, China; Team 10, student brigade trainees, the Second Military Medical University, Shanghai, China; Anpac Bio-Medical Science Co Ltd, Shanghai, China; Anpac Bio-Medical Science Technology Co., Ltd., Shanghai, China